1/13/2024 0 Comments Chrono cross time shifter codeAs a consequence of these weak zeitgeber conditions, the clocks of the vast majority have delayed and clash with our social, external time ( e.g., school/work hours) 1, 2. Light-dark cycles are however the most important signal (zeitgeber) used by the circadian clock for synchronization to the 24-h day. Modern lifestyle – characterised by living predominantly inside during the day and using electrical light at night – has altered our biological, internal timing by weakening the daily contrast between light and darkness. Composite Phase Deviations will help to understand the mechanisms that link ‘living against the clock’ with health and disease on an individual basis. Our method shows good congruence with published measures of circadian misalignment (i.e., Inter-daily Stability and ‘Behavioural Entrainment’), but offers added value as to its requirements, e.g., being computable for sleep logs and questionnaires. With increasing levels of circadian strain, the resulting shapes change systematically from small, connected forms to large and fragmented patterns. Based on a single time series, our Composite Phase Deviation method unveils distinct, subject- and schedule-specific geometries (‘islands and pancakes’) that illustrate how modern work times interfere with sleep. Here, we propose a novel method to quantify the mistiming of sleep-wake rhythms and demonstrate its versatility in day workers and shift workers. Sleeping at the ‘wrong’ internal time can jeopardise health and safety, and we therefore need a good quantification of this phenomenon. This strain is predominantly caused by external (societal) demands including shift work, early school start times and fast travels across time zones. Circadian misalignment describes the off-set between sleep-wake cycles and clock-regulated physiology. The circadian clock governs virtually all processes in the human body, including sleep-wake behaviour.
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